1H-Pyrrolo[3,2-c]pyridine, 3-bromo-
3-bromo-1H-pyrrolo[3,2-c]pyridine
CAS: 23612-36-4
Molecular Formula: C7H5BrN2
1H-Pyrrolo[3,2-c]pyridine, 3-bromo- - Names and Identifiers
| Name | 3-bromo-1H-pyrrolo[3,2-c]pyridine |
| Synonyms | 3-Bromo-5-azaindole 3-BROMO-5-AZAINDOLE 3-Bromo-1H-pyrrolo[3,2-c]pyridine 3-bromo-1H-pyrrolo[3,2-c]pyridine 1H-Pyrrolo[3,2-c]pyridine, 3-bromo- |
| CAS | 23612-36-4 |
| InChI | InChI=1/C7H5BrN2/c8-6-4-10-7-1-2-9-3-5(6)7/h1-4,10H |
1H-Pyrrolo[3,2-c]pyridine, 3-bromo- - Physico-chemical Properties
| Molecular Formula | C7H5BrN2 |
| Molar Mass | 197.03 |
| Density | 1.77g/cm3 |
| Boling Point | 357°C at 760 mmHg |
| Flash Point | 169.7°C |
| Vapor Presure | 5.79E-05mmHg at 25°C |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.727 |
1H-Pyrrolo[3,2-c]pyridine, 3-bromo- - Introduction
3-bromo-1h-pyrirolo [3,2-c]pyridine is an organic compound with the chemical formula C9H6BrN. It is a pale yellow crystal. The following is a description of the properties, uses, preparation methods and safety information of the compound:
Nature:
-Appearance: 3-bromo-1h-pyrirolo [3,2-c]pyridine is a pale yellow solid.
-Solubility: It has good solubility in common organic solvents, such as ethanol, dimethyl sulfoxide and dichloromethane.
-Melting point: The melting point of the compound is 140-143 degrees Celsius.
Use:
3-bromo-1h-pyrirolo [3,2-c]pyridine is widely used in organic synthesis and can be used as a drug intermediate or a drug active skeleton. It is often used in the synthesis of derivatives in the field of scientific research, such as potential anti-cancer drugs, anti-inflammatory drugs and so on. In addition, it can also be used as a precursor for electronic materials such as organic light emitting diodes (OLEDs).
Method:
A method for synthesizing 3-bromo-1h-pyrirolo [3,2-c]pyridine is to react indole and bromoethane under alkaline conditions. First, the indole and ethyl bromide are reacted in a basic medium (e. G., sodium carbonate solution) to form an intermediate product. Then, the final product is obtained by an acid treatment and a crystallization purification step.
Safety Information:
3-bromo-1h-pyrirolo [3,2-c]pyridine has less specific toxicity and hazard data. However, as an organic bromine compound, it may have certain irritant and toxic properties. Proper laboratory safety practices should be followed when handling and using the substance, such as wearing protective gloves, glasses and laboratory clothing to mitigate potential risks. In addition, care should be taken to avoid inhalation, ingestion or skin contact, and to ensure that the operation is carried out in a well-ventilated place. If necessary, it should be operated and handled under the guidance of professional personnel. In the event of an accident, appropriate emergency measures and medical treatment should be taken immediately.
Nature:
-Appearance: 3-bromo-1h-pyrirolo [3,2-c]pyridine is a pale yellow solid.
-Solubility: It has good solubility in common organic solvents, such as ethanol, dimethyl sulfoxide and dichloromethane.
-Melting point: The melting point of the compound is 140-143 degrees Celsius.
Use:
3-bromo-1h-pyrirolo [3,2-c]pyridine is widely used in organic synthesis and can be used as a drug intermediate or a drug active skeleton. It is often used in the synthesis of derivatives in the field of scientific research, such as potential anti-cancer drugs, anti-inflammatory drugs and so on. In addition, it can also be used as a precursor for electronic materials such as organic light emitting diodes (OLEDs).
Method:
A method for synthesizing 3-bromo-1h-pyrirolo [3,2-c]pyridine is to react indole and bromoethane under alkaline conditions. First, the indole and ethyl bromide are reacted in a basic medium (e. G., sodium carbonate solution) to form an intermediate product. Then, the final product is obtained by an acid treatment and a crystallization purification step.
Safety Information:
3-bromo-1h-pyrirolo [3,2-c]pyridine has less specific toxicity and hazard data. However, as an organic bromine compound, it may have certain irritant and toxic properties. Proper laboratory safety practices should be followed when handling and using the substance, such as wearing protective gloves, glasses and laboratory clothing to mitigate potential risks. In addition, care should be taken to avoid inhalation, ingestion or skin contact, and to ensure that the operation is carried out in a well-ventilated place. If necessary, it should be operated and handled under the guidance of professional personnel. In the event of an accident, appropriate emergency measures and medical treatment should be taken immediately.
Last Update：2024-04-09 21:01:54
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